plpro inhibitor — TargetMol Chemicals

Cat No.	Product Name	Targets
T12502	PLpro inhibitor	SARS-CoV
	PLpro inhibitor is a potent papain-like protease (PLpro) inhibitor(IC50 of 2.6 uM)	SARS-CoV
T78704	PLpro/RBD-IN-1	SARS-CoV
	PLpro/RBD-IN-1 (Compound 5) serves as a dual inhibitor targeting both the SARS-CoV-2 papain-like protease (PLpro) and the receptor-binding domain (RBD) of the spike protein, exhibiting half-maximal inhibitory concentrati...	SARS-CoV
T62991	Mpro/PLpro-IN-1
	Mpro/PLpro-IN-1 (Compound 29) is a dual-acting inhibitor of SARS-CoV-2 protease.Mpro/PLpro-IN-1 is also a potent inhibitor of Mpro/PLpro, with micromolar inhibition of M pro (IC50:1.72 μM) and submicromolar inhibition of...
T81203	SARS-CoV-2-IN-68	SARS-CoV
	SARS-CoV-2-IN-68 (compound 6C) is a covalent inhibitor of both SARS-CoV-2 PLpro and Mpro, exhibiting potent antiviral properties by targeting the Zn-finger domain of PLpro [1].	SARS-CoV
T79426	SARS-CoV-2-IN-61	SARS-CoV
	SARS-CoV-2-IN-61 (compound 8i) is a potent inhibitor of the SARS-CoV-2 PLpro, exhibiting an IC50 of 16 µM and demonstrating antiviral activities [1].	SARS-CoV
T63735	SP inhibitor 1
	SP inhibitor 1 is an inhibitor of SARS-CoV-2 replication at non-toxic concentrations (0.3250<5.98 μM) in vitro. SP inhibitor 1 is a selective inhibitor of SARS-CoV-2 stinger protein (SP), acting on SP protein (IC50: 3.26...
T60841	SARS-CoV-2-IN-23
	SARS-CoV-2-IN-23 (compound GRL-0617) is an inhibitor of SARS-COV-2 papain-like protease (PLpro) (IC 50 = 2.3 μM) [1].
T62928	XR8-69
	XR8-69 is a SARS-CoV-2 PLpro inhibitor. XR8-69 has a low micromolar antiviral effect in SARS-CoV-2 infected human cells.
T63292	SARS-CoV-2-IN-24
	SARS-CoV-2-IN-24 is a potent inhibitor of papain-like proteases (PLpro) that induces conformational changes in SARS-COV-2 papain-like proteases, inhibits SARS-COV-2 replication, and can be used to study SARS-CoV-2.
T63461	INSCoV-600K(1)
	INSCoV-600K(1) is a potent Mpro(3CLpro) inhibitor. Proteases (PLpro and 3CLpro) are associated with viral transcription and replication. INSCoV-600K(1) has shown research potential against SARS-CoV-2 infection.
T63483	INSCoV-614(1B)
	INSCoV-614(1B) is a potent Mpro(3CLpro) inhibitor. Proteases (PLpro and 3CLpro) are associated with viral transcription and replication. INSCoV-614(1B) has shown research potential for SARS-CoV-2 infection.
T63462	INSCoV-601I(1)
	INSCoV-601I(1) is a potent Mpro(3CLpro) inhibitor. Proteases (PLpro and 3CLpro) are associated with viral transcription and replication. INSCoV-600I(1) has shown research potential against SARS-CoV-2 infection.
T63443	XR8-89
	XR8-89, a potent inhibitor of papain-like protease (PLpro), exhibits an IC50 value of 0.1 μM and effectively hinders SARS-CoV-2 replication by inducing conformational changes in the SARS-COV-2 papain-like protease. This ...
T78953	SIMR3030	SARS-CoV
	SIMR3030, a potent inhibitor of SARS-CoV-2 PLpro, possesses an IC50 of 0.0399 µg/mL and demonstrates antiviral activity by diminishing the expression of SARS-CoV spike, ORF1b, IFN-α, and IL-6 mRNA. Additionally, SIMR3030...	SARS-CoV
T61500	PLP_Snyder530
	PLP_Snyder530 is a potent papain-like protease (PL pro ) inhibitor. PLP_Snyder530 induces conformational changes in SARS-COV-2 papain-like protease, inhibiting SARS-CoV-2 replication. PLP_Snyder530 can be used for SARS-C...
T81202	SARS-CoV-2-IN-69	SARS-CoV
	SARS-CoV-2-IN-69 (Compound 7E) is a potent, non-covalent inhibitor of the SARS-CoV-2 main protease (M^pro) with an EC50 of 7.4 μM and also inhibits the papain-like protease (PL^pro) [1].	SARS-CoV
T75065	Antiviral agent 25
	Antiviral agent 25 (compound 6g), a novel non-peptide analog covalent inhibitor of SARS-CoV-2 3CL pro, exhibits robust inhibitory activity against both SARS-CoV-2 3CL pro and SARS-CoV-2 PL pro, with IC50 values of 0.118 ...